Well, it seems to me that the best relationships, the ones that last, are frequently the ones that are rooted in friendship. You know, one day you look at the person and you see something more than you did the night before. Like a switch has been flicked somewhere. And the person who was just a friend is… suddenly the only person you can ever imagine yourself with. - X-Files
Doctor Who
Doctor/Rose (OTP), Doctor/TARDIS, Amy/Rory, Amy/Rory/Eleven.
Harry Potter
Harry/Hermione (OTP), Harry/Draco, Sirius/Remus, Rony/Luna, Draco/Ginny, Neville/Ginny, Albus/Scorpius, Snape/Lilly.
Supernatural
Sam/Dean (OTP), Dean/Castiel/Sam, John/Mary.
The Vampire Diaries
Damon/Elena (OTP), Stefan/Caroline, Stefan/Rebekah, Stefan/Katherine, Tyler/Caroline, Alaric/Jenna and Jeremy/Anna.
Fringe
Peter/Olivia (OTP), Walter/Astrid.
Sherlock
Sherlock/John (OTP).
Bones
Booth/Brennan (OTP), Hodgins/Angela.
Once Upon A Time
Rumpelstiltskin/Belle (OTP), Prince Charming/Snow White.
The Secret Circle
Jake/Cassie (OTP), Adam/Diana.
The Big Bang Theory
Sheldon/Penny (OTP), Howard/Bernadette.
Merlin
Merlin/Arthur (OTP), Uther/Morgana, Gwen/Lancelot.
Pretty Little Liars
Toby/Spencer (OTP), Caleb/Hanna, Ezra/Aria.
Suits
Harvey/Mike (OTP), Harvey/Donna, Mike/Rachel.
Glee
Puck/Kurt (OTP), Sam/Kurt, Jesse/Rachel, Will/Emma.
The Borgias
Cesare/Lucrezia (OTP).
Queer as Folk
Michael/Ben (OTP), Michael/Brian, Brian/Justin, Ted/Emmett.
X-Files
Mulder/Scully (OTP).
Other OTP’s
Pacey/Joey (Dawson’s Creek), Jeannie/Nelson (A Dream of Jeannie), Miranda/Gary (Miranda), Chris/Oliver (Verbotene Liebe), Samantha/Todd (Samantha Who?), Padmé/Anakin (Star Wars), Percy/Annabeth (Percy Jackson), Clark/Chloe (Smallville), Luke/Lorelai (Gilmore Girls), Landon/Jamie (A Walk To Remember), Ariel/Eric (The Little Mermaid), Beast/Belle (Beauty and the Beast), Li Shang/Mulan (Mulan), Rapunzel/Flynn (Rapunzel), Nala/Simba (The Lion King), Pocahontas/John Rolfe (Pocahontas II).